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(11)

EP 1 058 500 A1

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(43) Date of publication: 13.12.2000 Bulletin 2000/50 (21) Application number: 99909641.5 (22) Date of filing: 26.02.1999

(51) International Patent Classification (IPC)7: A01N 37/18, A61K 31/00, A61K 38/16, C07H 21/02, C07K 16/00, C12N 1/14, C12N 1/20, C12N 5/00, C12N 15/00, C12P 21/06, C12Q 1/68 (86) International application number: PCT/US9904/224 (87) International publication number: WO 9943/208 (02.09.1999 Gazette 1999/35)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 27.02.1998 US 76325 P (71) Applicant: THE GENERAL HOSPITAL CORPORATION Boston, MA 02110 (US)	(72) Inventors: GEORGOPOULOS, Katia Cambridge, MA 02138 (US) MORGAN, Bruce, A. Lexington, MA 02173 (US) KELLEY, Clair Sommerville, MA 02144 (US) (74) Representative: Ruffles, Graham Keith et al MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)