(19)

(11)

EP 1 058 557 A1

(12)

(43) Date of publication: 13.12.2000 Bulletin 2000/50 (21) Application number: 99911081.0 (22) Date of filing: 04.03.1999

(51) International Patent Classification (IPC)7: A61K 39/39, A61K 39/02, A61K 39/145, A61K 39/12 (86) International application number: PCT/US9904/678 (87) International publication number: WO 9944/635 (10.09.1999 Gazette 1999/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.03.1998 US 35188 (71) Applicant: THE MEDICAL COLLEGE OF OHIO Toledo, OH 43606 (US)	(72) Inventors: METZGER, Dennis, W. Sylvania, OH 43560 (US) ARULANANDAM, Bernard, P. Toledo, OH 43614 (US) (74) Representative: Holdcroft, James Gerald, Dr. et al Graham Watt & Co.,Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)