(19)

(11)

EP 1 059 918 A1

(12)

(43) Date of publication: 20.12.2000 Bulletin 2000/51 (21) Application number: 99901758.5 (22) Date of filing: 20.01.1999

(51) International Patent Classification (IPC)7: A61K 9/28, A61K 9/48 (86) International application number: PCT/GB9900/193 (87) International publication number: WO 9937/290 (29.07.1999 Gazette 1999/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 22.01.1998 GB 9801363 (71) Applicant: West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Nottingham NG7 2TN (GB)	(72) Inventors: WATTS, Peter, James Nottingham NG2 6DR (GB) ILLUM, Lisbeth Nottingham NG7 1BA (GB) (74) Representative: Dee, Ian Mark  Eric Potter Clarkson,Park View House,58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)