(19)

(11)

EP 1 060 184 A1

(12)

(43) Date of publication: 20.12.2000 Bulletin 2000/51 (21) Application number: 99908345.4 (22) Date of filing: 22.02.1999

(51) International Patent Classification (IPC)7: C07H 21/02, C07K 16/00, C07K 14/00, C12N 15/63, C12P 19/34, C12Q 1/00 (86) International application number: PCT/US9903/790 (87) International publication number: WO 9943/695 (02.09.1999 Gazette 1999/35)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 25.02.1998 US 75941 P 18.12.1998 US 112926 P (71) Applicants: MERCK & CO., INC. Rahway, New Jersey 07065 (US) Uppsala University 75105 Uppsala (SE) Wadelius, Claes 751 05 Uppsala (SE)	(72) Inventors: PETRUKHIN, Konstantin Rahway, NJ 07065 (US) CASKEY, C., Thomas Rahway, NJ 07065 (US) METZKER, Michael Rahway, NJ 07065 (US) WADELIUS, Claes S-751 05 Uppsala (SE) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)