(19)

(11)

EP 1 060 192 A2

(12)

(88) Date of publication A3: 14.10.1999 (43) Date of publication: 20.12.2000 Bulletin 2000/51 (21) Application number: 99907325.7 (22) Date of filing: 25.02.1999

(51) International Patent Classification (IPC)7: C07K 14/605 (86) International application number: PCT/DK9900/080 (87) International publication number: WO 9943/361 (02.09.1999 Gazette 1999/35)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 27.02.1998 DK 27198 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)

(72) Inventors: KNUDSEN, Liselotte, Bjerre DK-2500 Valby (DK) HUUSFELDT, Per, Olaf DK-1411 Copenhagen K (DK) NIELSEN, Per, Franklin DK-3500 V rl se (DK) KAARSHOLM, Niels, C. DK-2720 Vanl se (DK) OLSEN, Helle, Birk DK-3450 Aller d (DK) THIM, Lars DK-2820 Gentofte (DK) BJ RN, S ren, Erik DK-2800 Lyngby (DK) (74) Representative: Kjerrumgaard, Lars et al Novo Nordisk A/SCorporate PatentsNovo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)