(19)
(11) EP 1 061 919 A1

(12)

(43) Date of publication:
27.12.2000 Bulletin 2000/52

(21) Application number: 99912345.8

(22) Date of filing: 09.03.1999
(51) International Patent Classification (IPC)7A61K 31/435, C07D 211/14, C07D 211/56, C07D 221/02, C07D 221/06
(86) International application number:
PCT/US9905/131
(87) International publication number:
WO 9945/925 (16.09.1999 Gazette 1999/37)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 10.03.1998 US 77402 P
10.11.1998 US 107902 P

(71) Applicants:
  • Carrol, Frank Ivy
    Durham, NC 27712 (US)
  • Mascarella, Wayne S.
    Research Triangle Park, NC 27709-2194 (US)
  • Thomas, James B.
    Chapel Hill, NC 27516 (US)

(72) Inventors:
  • Carrol, Frank Ivy
    Durham, NC 27712 (US)
  • Mascarella, Wayne S.
    Research Triangle Park, NC 27709-2194 (US)
  • Thomas, James B.
    Chapel Hill, NC 27516 (US)

(74) Representative: Audier, Philippe André et al
c/o Société de Protection des Inventions,3, rue du Docteur Lancereaux
75008 Paris
75008 Paris (FR)

   


(54) NOVEL OPIATE COMPOUNDS, METHODS OF MAKING AND METHODS OF USE