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(11)

EP 1 062 215 A1

(12)

(43) Date of publication: 27.12.2000 Bulletin 2000/52 (21) Application number: 99905941.3 (22) Date of filing: 10.02.1999

(51) International Patent Classification (IPC)7: C07D 401/12, C07D 215/06, C07D 471/04, C07D 487/06 (86) International application number: PCT/US9902/918 (87) International publication number: WO 9941/252 (19.08.1999 Gazette 1999/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 11.02.1998 US 74411 P 17.03.1998 GB 9805717 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: YOUNG, Jonathan, R. Rahway, NJ 07065 (US) GOULET, Mark, T. Rahway, NJ 07065 (US) WALSH, Thomas, F. Rahway, NJ 07065 (US) FISHER, Michael, H. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)