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(11)

EP 1 062 319 A1

(12)

(43) Date of publication: 27.12.2000 Bulletin 2000/52 (21) Application number: 99912320.1 (22) Date of filing: 10.03.1999

(51) International Patent Classification (IPC)7: C12N 1/21, C12N 5/10, C12N 15/18, C12N 15/63, C12Q 1/00, C12Q 1/68, C12Q 1/70, A61K 38/18, C07K 14/50, C07K 16/22 (86) International application number: PCT/US9905/021 (87) International publication number: WO 9946/364 (16.09.1999 Gazette 1999/37)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.03.1998 US 42105 30.06.1998 US 107997 (71) Applicant: HUMAN GENOME SCIENCES, INC. Rockville, MD 20850-3338 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsville, MD 20882 (US) CAO, Liang Hong Kong (CN) HU, Jing-Shan Sunnyvale, CA 94086 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)