(19)
(11) EP 1 063 988 A1

(12)

(43) Date of publication:
03.01.2001 Bulletin 2001/01

(21) Application number: 98951777.6

(22) Date of filing: 20.10.1998
(51) International Patent Classification (IPC)7A61K 31/35
(86) International application number:
PCT/KR9800/324
(87) International publication number:
WO 9921/549 (06.05.1999 Gazette 1999/18)
(84) Designated Contracting States:
DE FR GB IT

(30) Priority: 28.10.1997 KR 9755578
28.03.1998 KR 9810888
08.04.1998 KR 9812411
14.04.1998 KR 9813283

(71) Applicant: Korea Institute of Science and Technology
Seoul 136-130 (KR)

(72) Inventors:
  • BOK, Song Hae
    Daejeon 302-222 (KR)
  • JEONG, Tae Sook
    Daejeon 305-333 (KR)
  • CHOI, Myung Sook
    Daegu 706-014 (KR)
  • MOON, Surk Sik
    Gongju-shiChungcheongnam-do 314-110 (KR)
  • KWON, Yong Kook
    Daejeon 305-333 (KR)
  • LEE, Eun Sook
    Daejeon 301-013 (KR)
  • HYUN, Byung Hwa
    Daejeon 305-333 (KR)
  • CHOI, Yang-Kyu
    Daejeon 305-333 (KR)
  • LEE, Chui Ho
    Daejeon 302-171 (KR)
  • BAE, Ki Hwan
    Daejeon 302-200 (KR)
  • PARK, Yong Bok
    Daegu 706-014 (KR)
  • LEE, Jun Sung
    Daejeon 302-280 (KR)
  • LEE, Jun Sung
    Daejeon 302-280 (KR)
  • LEE, Jun Sung
    Daejeon 302-280 (KR)
  • SON, Kwang Hee
    Daejeon 305-333 (KR)
  • KWON, Byoung Mog
    Daejeon 302-340 (KR)
  • KIM, Young Kook
    Daejeon 305-333 (KR)
  • CHOI, Doil
    Daejeon 305-340 (KR)
  • KIM, Sung Uk
    Daejeon 305-333 (KR)
  • HWANG, Ingyu
    Daejeon 305-340 (KR)
  • AHN, Jung Ah
    Daejeon 300-092 (KR)
  • PARK, Young Bae
    Seoull, 135-110 (KR)
  • KIM, Hyo Soo
    Seoul, 135-110 (KR)
  • CHOE, Seong Choon
    Seoul 121-040 (KR)

(74) Representative: Goddar, Heinz J., Dr. 
FORRESTER & BOEHMERTFranz-Joseph-Strasse 38
80801 München
80801 München (DE)

   


(54) HESPERIDIN AND HESPERETIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OFMACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES