(19)

(11)

EP 1 063 993 A1

(12)

(43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99911940.7 (22) Date of filing: 24.03.1999

(51) International Patent Classification (IPC)7: A61K 31/445, A61K 9/14 (86) International application number: PCT/GB9900/922 (87) International publication number: WO 9948/499 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: RO SI (30) Priority: 24.03.1998 GB 9806312 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: CRAIG, Andrew, S.,Smithkline Beecham Pharma. Tonbridge,Kent TN11 9AN (GB) WARD, Neal,SmithKline Beecham Pharmaceuticals Tonbridge,Kent TN11 9AN (GB) (74) Representative: West, Vivien et al SmithKline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)