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(11)

EP 1 064 302 A1

(12)

(43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99912673.3 (22) Date of filing: 18.03.1999

(51) International Patent Classification (IPC)7: C07K 14/00, C07K 7/00, C12N 5/10, C12N 15/10, C12N 15/11, C12N 15/12, C12N 15/63, A61K 38/00 (86) International application number: PCT/US9905/939 (87) International publication number: WO 9947/555 (23.09.1999 Gazette 1999/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.03.1998 US 78803 P (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)

(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) McCOY, John, M. Reading, MA 01720 (US) LaVALLIE, Edward, R. Harvard, MA 01451 (US) COLLINS-RACIE, Lisa, A. Acton, MA 01720 (US) EVANS, Cheryl Germantown, MA 20874 (US) MERBERG, David Acton, MA 01720 (US) TREACY, Maurice Dublin 18 (IE) AGOSTINO, Michael, J. Andover, MA 01810 (US) STEININGER, Robert, J., II Cambridge, MA 02140 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)