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(11)

EP 1 064 364 A1

(12)

(43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99912689.9 (22) Date of filing: 18.03.1999

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/12, C07K 14/00, C07K 14/435 (86) International application number: PCT/US9905/993 (87) International publication number: WO 9949/023 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 23.03.1998 US 46316 (71) Applicant: SMITHKLINE BEECHAM CORPORATION PhiladelphiaPennsylvania 19103 (US)	(72) Inventors: HENSLEY, Preston Chester Springs, PA 19425 (US) ROSE, George, D. Glen Arm, MD 21057 (US) AURORA, Rajeev Chesterfield, MO 93005 (US) ABDEL-MEGUID, Sherin, S. Exton, PA 19341 (US) YOUNG, Peter, R. Lawrenceville, NJ 08648 (US) ZHU, Yuan Blue Bell, PA 19422 (US) (74) Representative: Crump, Julian Richard John et al FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)