(19)

(11)

EP 1 064 371 A2

(12)

(88) Date of publication A3: 18.11.1999 (43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99912218.7 (22) Date of filing: 16.03.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C07K 16/28, G01N 33/68, C12N 1/21, C12N 5/10, C12N 1/19, C12Q 1/68, A61K 39/395, A61K 38/17, A61K 31/70 (86) International application number: PCT/US9903/740 (87) International publication number: WO 9947/673 (23.09.1999 Gazette 1999/38)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 17.03.1998 US 40111 (71) Applicant: SCHERING CORPORATION KenilworthNew Jersey 07033 (US)

(72) Inventors: CHALUS, Lionel F-69570 Dardilly (FR) QUAN, Ahn, B. San Jose, CA 95126 (US) BATES, Elizabeth, Esther, Mary F-69001 Lyon (FR) GORMAN, Daniel, M. Newark, CA 94560 (US) SAELAND, Sem F-69005 Lyon (FR) LEBECQUE, Serge, J., E. F-69380 Civrieux d'Azergue (FR) PHILIPPS, Joseph, H., Jr. Palo Alto, CA 94303 (US) (74) Representative: Almond-Martin, Carol et al Ernest Gutmann - Yves Plasseraud S.A.3, rue Chauveau-Lagarde 75008 Paris 75008 Paris (FR)