(19)
(11) EP 1 064 373 A2

(12)

(88) Date of publication A3:
18.11.1999

(43) Date of publication:
03.01.2001 Bulletin 2001/01

(21) Application number: 99912727.7

(22) Date of filing: 18.03.1999
(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/82, A61K 38/17, G01N 33/68, C12N 15/63, C12N 5/10
(86) International application number:
PCT/US9906/051
(87) International publication number:
WO 9947/557 (23.09.1999 Gazette 1999/38)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 18.03.1998 US 78634 P

(71) Applicants:
  • ONYX PHARMACEUTICALS, INC.
    Richmond, CA 94806 (US)
  • BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM
    Austin, Texas 78701 (US)

(72) Inventors:
  • BOLLAG, Gideon
    Hercules, CA 94547 (US)
  • HART, Matthew, J.
    Berkeley, CA 94706 (US)
  • ROSCOE, William
    San Francisco, CA 94115 (US)
  • POLAKIS, Paul
    Mill Valley, CA 94941 (US)
  • STERNWEIS, Paul
    Richardson, TX 75080 (US)
  • KOZASA, Tohru
    Dallas, TX 75225 (US)
  • JIANG, Xuejun
    Richardson, TX 75080 (US)

(74) Representative: Cripps, Joanna Elizabeth et al
Mewburn EllisYork House23 Kingsway
GB-London WC2B 6HP
GB-London WC2B 6HP (GB)

   


(54) IDENTIFICATION OF FACTORS WHICH MEDIATE THE INTERACTION OF HETEROTRIMERIC G PROTEINS AND MONOMERIC G PROTEINS