(19)

(11)

EP 1 064 378 A2

(12)

(88) Date of publication A3: 20.01.2000 (43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99916187.0 (22) Date of filing: 29.03.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/70, C07K 16/18, A61K 31/70, C07K 14/435, C07K 14/47, A61K 39/00, A61K 48/00, C12Q 1/68, G01N 33/577, C12N 15/79 (86) International application number: PCT/US9906/860 (87) International publication number: WO 9948/916 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.03.1998 US 49719 (71) Applicants: THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY Palo Alto, CA 94304-1850 (US) SRI INTERNATIONAL Menlo Park,California 94025-3493 (US)

(72) Inventors: DENKO, Nicholas, C. Menlo Park, CA 94025 (US) GIACCIA, Amato, J. Stanford, CA 94305 (US) GREEN, Christopher, J. Novato, CA 94945 (US) LADEROUTE, Keith, R. Palo Alto, CA 94301 (US) SCHINDLER, Cornelia Palo Alto, CA 94306 (US) KOONG, Albert, Ching-Wei Los Altos, CA 94024 (US) (74) Representative: HOFFMANN - EITLE  Patent- und RechtsanwälteArabellastrasse 4 81925 München 81925 München (DE)