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(11)

EP 1 064 388 A1

(12)

(43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99916852.9 (22) Date of filing: 17.03.1999

(51) International Patent Classification (IPC)7: C12N 15/57, C12N 9/64, C07K 16/40, C12N 15/11, C12N 7/01, C12Q 1/68, G01N 33/68, A61K 31/70, A61K 38/48 (86) International application number: PCT/EP9901/894 (87) International publication number: WO 9949/055 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.03.1998 GB 9806095 (71) Applicant: SMITHKLINE BEECHAM BIOLOGICALS (S.A.),formerly SMITHKLINE BIOLOGICALS (S.A.) 1330 Rixensart (BE)	(72) Inventors: BRUCK, Claudine E. M.,SmithKline Beecham Bio.S.A. 1330 Rixensart (BE) CASSART, Jean-Pol,SmithKline Beecham Bio. S.A. 1330 Rixensart (BE) COCHE, Thierry,SmithKline Beecham Bio. S.A. 1330 Rixensart (BE) VINALS-BASSOLS, Carlota 1330 Rixensart (BE) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)