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EP 1 064 390 A1

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(43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99912714.5 (22) Date of filing: 19.03.1999

(51) International Patent Classification (IPC)7: C12N 15/63, C12N 15/85, A61K 35/00, A61K 39/00, A61K 48/00 (86) International application number: PCT/US9906/037 (87) International publication number: WO 9947/687 (23.09.1999 Gazette 1999/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 20.03.1998 US 78900 P (71) Applicant: Genzyme Corporation Framingham, MA 01701-9322 (US)	(72) Inventors: KAPLAN, Johanne Sherborn, MA 01702 (US) SCARIA, Abraham Framingham, MA 01702 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)