(19)

(11)

EP 1 064 392 A2

(12)

(88) Date of publication A3: 18.11.1999 (43) Date of publication: 03.01.2001 Bulletin 2001/01 (21) Application number: 99912601.4 (22) Date of filing: 16.03.1999

(51) International Patent Classification (IPC)7: C12N 15/86, A61K 48/00 (86) International application number: PCT/US9905/781 (87) International publication number: WO 9947/690 (23.09.1999 Gazette 1999/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.03.1998 US 78205 P (71) Applicant: Introgen Therapeutics, Inc. Austin, TX 78701 (US)	(72) Inventors: ALMOND, Brian, D. Fitchburg, WI 53711 (US) WILSON, Deborah Houston, TX 77031 (US) CHADA, Sunil Missouri City, TX 77459 (US) ZUMSTEIN, Louis, A. Houston, TX 77019 (US) (74) Representative: Gowshall, Jonathan Vallance et al FORRESTER & BOEHMERTFranz-Joseph-Strasse 38 80801 München 80801 München (DE)