(19)

(11)

EP 1 066 061 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99914117.9 (22) Date of filing: 26.03.1999

(51) International Patent Classification (IPC)7: A61K 48/00 (86) International application number: PCT/US9906/452 (87) International publication number: WO 9948/537 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.03.1998 US 48813 (71) Applicant: LONG ISLAND JEWISH MEDICAL CENTER NEW HYDE Park, NY 11042 (US)	(72) Inventors: GOLDBERG, Itzhak, D. Englewood, NJ 07631 (US) ROSEN, Eliot, M. Port Washington, NY 11050 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)