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EP 1 066 269 A1

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(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99917863.5 (22) Date of filing: 24.03.1999

(51) International Patent Classification (IPC)7: C07D 251/70, C07D 251/52, A61K 31/53, C07D 403/12, C07D 251/42, C07D 251/50, C07D 251/66 (86) International application number: PCT/EP9902/044 (87) International publication number: WO 9950/256 (07.10.1999 Gazette 1999/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT LV MK RO SI (30) Priority: 27.03.1998 US 79633 P 14.05.1998 EP 98201589 (71) Applicant: JANSSEN PHARMACEUTICA N.V. 2340 Beerse (BE)

(72) Inventors: DAEYAERT, Frederik, Frans, Desiré B-2020 Antwerpen (BE) DE CORTE, Bart Southampton, PA 18966 (US) DE JONGE, Marc, René NL-5045 CA Tilburg (NL) HEERES, Jan B-2350 Vosselaar (BE) HO, Chih, Yung Lansdale, PA 19446 (US) JANSSEN, Paul, Adriaan, Jan B-2350 Vosselaar (BE) KAVASH, Robert, W. Glenside, PA 19038 (US) KOYMANS, Lucien, Maria, Henricus B-2470 Retie (BE) KUKLA, Michael, Joseph Maple Glen, PA 19002 (US) LUDOVICI, Donald, William Quakertown, PA 18951 (US) (74) Representative: Allard, Susan Joyce et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)