(19)

(11)

EP 1 066 273 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 98913910.0 (22) Date of filing: 25.03.1998

(51) International Patent Classification (IPC)7: C07D 295/18, A61K 31/435 (86) International application number: PCT/GB9800/914 (87) International publication number: WO 9948/881 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (71) Applicant: BRITISH BIOTECH PHARMACEUTICALS LIMITED CowleyOxford, OX4 5LY (GB)	(72) Inventors: BECKETT, Raymond, Paul Cowley,Oxford OX4 5LY (GB) MARTIN, Fionna, Mitchell Cowley,Oxford OX4 5LY (GB) MILLER, Andrew Cowley,Oxford OX4 5LY (GB) TODD, Richard, Simon Cowley,Oxford OX4 5LY (GB) (74) Representative: Walls, Alan James et al British Biotech Pharmaceuticals Ltd,Watlington Road Cowley,Oxford OX4 5LY Cowley,Oxford OX4 5LY (GB)