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(11)

EP 1 066 285 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99914212.8 (22) Date of filing: 29.03.1999

(51) International Patent Classification (IPC)7: C07D 471/04, A61K 31/435 (86) International application number: PCT/US9906/728 (87) International publication number: WO 9951/595 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.04.1998 US 80396 P 05.06.1998 GB 9812217 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: WALSH, Thomas, F. Rahway, NJ 07065 (US) UJJAINWALLA, Feroze Rahway, NJ 07065 (US) GOULET, Mark, T. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)