(19)

(11)

EP 1 066 288 A2

(12)

(88) Date of publication A3: 30.09.2000 (43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99910228.8 (22) Date of filing: 12.02.1999

(51) International Patent Classification (IPC)7: C07D 487/00 (86) International application number: PCT/EP9901/013 (87) International publication number: WO 9942/465 (26.08.1999 Gazette 1999/34)

(84) Designated Contracting States: BE CH DE ES FR GB IT LI NL (30) Priority: 18.02.1998 GB 9803411 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: BROMIDGE, Steven, MarkSmithKline Beecham Pharma. HarlowEssex CM19 5AW (GB) SERAFINOWSKA, Halina, T.SmithKline Beecham Pharma Harlow,Essex CM19 5AW (GB) (74) Representative: Waters, David Martin, Dr. et al Smithkline Beecham plcCorporate Intellectual Property,Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)