(19)

(11)

EP 1 066 320 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99914221.9 (22) Date of filing: 26.03.1999

(51) International Patent Classification (IPC)7: C07K 14/00, C07K 14/435, C07K 14/705, C12N 5/16, C12N 15/12, C12N 15/62, C12N 15/63, G01N 33/53, G01N 33/566 (86) International application number: PCT/US9906/737 (87) International publication number: WO 9948/915 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.03.1998 US 79593 P (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)	(72) Inventors: KLIEWER, Steven Anthony,Glaxo Wellcome Inc. Research Triangle Park, NC 27709 (US) WILLSON, Timothy Mark,Glaxo Wellcome Inc. Research Triangle Park, NC 27709-3398 (US) (74) Representative: Thornley, Rachel Mary et al Glaxo Wellcome plc,Glaxo Wellcome House,Berkeley Avenue Greenford,Middlesex UB6 0NN Greenford,Middlesex UB6 0NN (GB)