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(11)

EP 1 066 325 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99915243.2 (22) Date of filing: 02.04.1999

(51) International Patent Classification (IPC)7: C07K 14/705, C12N 15/12, C12N 15/62, A61K 38/17 (86) International application number: PCT/US9907/333 (87) International publication number: WO 9951/641 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.04.1998 US 80671 P (71) Applicant: NPS PHARMACEUTICALS, INC. Salt Lake CityUtah 84108 (US)

(72) Inventors: STORMANN, Thomas, M. Salt lake City, UT 84105 (US) HAMMERLAND, Lance, G. Salt Lake City, UT 84010 (US) STORJOHANN, Laura, L. Salt Lake City, UT 84117 (US) BUSBY, James, G. Salt Lake City, UT 84109 (US) GARRETT, James, E. Salt Lake City, UT 84106 (US) SIMIN, Rachel, T. Salt Lake City, UT 84105 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)