(19)

(11)

EP 1 066 327 A2

(12)

(88) Date of publication A3: 16.09.1999 (43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99901731.2 (22) Date of filing: 18.01.1999

(51) International Patent Classification (IPC)7: C07K 16/00 (86) International application number: PCT/GB9900/152 (87) International publication number: WO 9936/440 (22.07.1999 Gazette 1999/29)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.01.1998 GB 9800927 (71) Applicant: THE VICTORIA UNIVERSITY OF MANCHESTER Manchester M13 9PL (GB)	(72) Inventors: HAWKINS, Robert, Edward Manchester M20 4BX (GB) WHITTINGTON, Hayley, Ann,Bristol Oncology Centre Bristol BS2 8ED (GB) (74) Representative: Stark, Amanda Jane  Marks & Clerk,Sussex House,83-85 Mosley Street Manchester M2 3LG Manchester M2 3LG (GB)