(19)

(11)

EP 1 066 371 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99908186.2 (22) Date of filing: 12.02.1999

(51) International Patent Classification (IPC)7: C12N 5/10, C12N 15/64 (86) International application number: PCT/US9903/307 (87) International publication number: WO 9947/647 (23.09.1999 Gazette 1999/38)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.03.1998 US 40961 06.08.1998 US 130114 (71) Applicant: PHARMACOPEIA, INC. Cranbury, NJ 08512 (US)	(72) Inventors: HORLICK, Robert, A. Plainsboro, NJ 08536 (US) ROBBINS, Alan, K. Wilmington, DE 19809 (US) DAMAJ, Bassam, B. Lawrenceville, NJ 08648 (US) (74) Representative: White, Martin Paul et al Lloyd Wise, Tregear & Co.Commonwealth House1-19 New Oxford Street GB-London WC1A 1LW GB-London WC1A 1LW (GB)