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EP 1 066 377 A1

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(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99915026.1 (22) Date of filing: 25.03.1999

(51) International Patent Classification (IPC)7: C12N 15/09, C12N 15/11, C12N 15/63, A61K 48/00, A61K 35/00, A61K 38/43 (86) International application number: PCT/US9906/491 (87) International publication number: WO 9949/027 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 25.03.1998 US 47918 01.03.1999 US 122270 P 01.03.1999 US 122268 P 09.03.1999 US 123669 P 09.03.1999 US 123670 P (71) Applicant: Cutanogen, Inc. Sudbury, MA 01776 (US)

(72) Inventors: SCHWARTZ, Gary, G. Miami, FL 33189 (US) LOKESHWAR, Balakrishna, L. Miami, FL 33176 (US) CHEN, Tai, C. Sudbury, MA 01776 (US) WHITLATCH, Lyman, W. Boston, MA 02118 (US) KONG, Xiang, Fu Newton, MA 02460 (US) HOLICK, Michael, F. Sudbury, MA 01776 (US) (74) Representative: Schlich, George William et al Mathys & SquireEuropean Patent Attorneys,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)