(19)

(11)

EP 1 066 381 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99947073.5 (22) Date of filing: 25.01.1999

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/11, C12N 15/85, C12N 5/10, C07K 14/705 (86) International application number: PCT/EP9900/420 (87) International publication number: WO 9937/765 (29.07.1999 Gazette 1999/39)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 27.01.1998 EP 98300549 26.10.1998 GB 9823421 20.01.1999 GB 9901209 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford,Middlesex TW8 9EP (GB)	(72) Inventors: DAVIS, John Beresford,SmithKline Beecham Pharm. Harlow, Essex CM19 5AW (GB) DUCKWORTH, David Malcolm,SmithKline Beecham Phar. Harlow, Essex CM19 5AW (GB) HAYES, Philip David,SmithKline Beecham Pharmaceut Harlow, Essex CM19 5AW (GB) (74) Representative: Crump, Julian Richard John et al FJ Cleveland,40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)