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(11)

EP 1 066 382 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 98937928.4 (22) Date of filing: 23.07.1998

(51) International Patent Classification (IPC)7: C12N 15/18, C07K 14/475, C12N 5/10, G01N 33/68, G01N 33/53, A61K 38/18 (86) International application number: PCT/US9809/801 (87) International publication number: WO 9905/278 (04.02.1999 Gazette 1999/05)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.07.1997 US 53549 P (71) Applicant: BRIGHAM & WOMEN'S HOSPITAL, INC. Boston,Massachusetts 02115 (US)	(72) Inventors: SHINOHARA, Toshimichi Chestnut Hill, MA 02167 (US) SINGH, Dhirenda Brookline, MA 02146 (US) CHYLACK, Leo, T., Jr. Duxbury, MA 02331 (US) (74) Representative: Jump, Timothy John Simon et al Venner Shipley & Co.20 Little Britain London EC1A 7DH London EC1A 7DH (GB)