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(11)

EP 1 066 383 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99901552.2 (22) Date of filing: 27.01.1999

(51) International Patent Classification (IPC)7: C12N 15/40, C12N 15/82, C07K 14/08, A61K 39/12, A01H 5/00, C12P 21/02 (86) International application number: PCT/CA9900/064 (87) International publication number: WO 9937/784 (29.07.1999 Gazette 1999/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.01.1998 CA 2221843 (71) Applicants: Her Majesty in Right of Canada, as represented by The Minister of Agriculture and Agri-Food Canada London,Ontario N5V 4T3 (CA) University of Guelph Guelph,Ontario N1G 2W1 (CA)

(72) Inventors: RYMERSON, Robert,Agri. and Agri-Food Canada London,Ontario N5V 4T3 (CA) ZHANG, Jian,University of Guelph Guelph,Ontario N1G 2W1 (CA) YOO, Dongwan,University of Guelph Guelph,Ontario N1G 2W1 (CA) ERICKSON, Larry,University of Guelph Guelph,Ontario N1G 2W1 (CA) BRANDLE, Jim,Agriculture and Agri-Food Canada London,Ontario N5V 4T3 (CA) (74) Representative: Caldwell, Judith Margaret et al David Keltie Associates,12 New Fetter Lane London EC4A 1AG London EC4A 1AG (GB)