(19)

(11)

EP 1 066 387 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99912721.0 (22) Date of filing: 19.03.1999

(51) International Patent Classification (IPC)7: C12N 15/54, C12N 9/10, C12Q 1/68, C12Q 1/48 (86) International application number: PCT/US9906/045 (87) International publication number: WO 9949/053 (30.09.1999 Gazette 1999/39)

(84) Designated Contracting States: DE FR GB (30) Priority: 26.03.1998 US 79430 P (71) Applicant: E.I. DU PONT DE NEMOURS & COMPANY INCORPORATED WilmingtonDelaware 19898 (US)	(72) Inventors: CAHOON, Rebecca, E. Wilmington, DE 19806 (US) KINNEY, Anthony, J. Wilmington, DE 19809 (US) RAFALSKI, J., Antoni Wilmington, DE 19810 (US) RENDINA, Alan, R. Wilmington, DE 19808 (US) (74) Representative: Webber, Philip Michael  Frank B. Dehn & Co.,179 Queen Victoria Street London EC4V 4EL London EC4V 4EL (GB)