(19)

(11)

EP 1 066 391 A2

(12)

(88) Date of publication A3: 02.12.1999 (43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99913478.6 (22) Date of filing: 29.03.1999

(51) International Patent Classification (IPC)7: C12N 15/62, C12N 5/10, C12N 7/01, C12N 7/02, C07K 14/025, C07K 19/00, A61K 39/12 (86) International application number: PCT/GB9900/978 (87) International publication number: WO 9950/424 (07.10.1999 Gazette 1999/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.03.1998 GB 9806666 (71) Applicants: Stanley, Margaret Anne Cambridge CB1 2HF (GB) Zhang, Wei Cambridge CB1 3RW (GB)	(72) Inventors: Stanley, Margaret Anne Cambridge CB1 2HF (GB) Zhang, Wei Cambridge CB1 3RW (GB) (74) Representative: Walton, Seán Malcolm et al MEWBURN ELLIS,York House,23 Kingsway London WC2B 6HP London WC2B 6HP (GB)