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EP 1 066 398 A1

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(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99915013.9 (22) Date of filing: 26.03.1999

(51) International Patent Classification (IPC)7: C12P 21/00, C12N 15/12, C07K 14/47 (86) International application number: PCT/US9906/459 (87) International publication number: WO 9950/435 (07.10.1999 Gazette 1999/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.03.1998 US 49652 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge,Massachusetts 02140 (US)	(72) Inventors: BOWMAN, Michael, R. Canton, MA 02021 (US) LOHMAR, Patricia, D. Belmont, MA 02178 (US) WOOD, Nancy, L. Somrville, MA 02143 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)