(19)

(11)

EP 1 066 404 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99917335.4 (22) Date of filing: 02.04.1999

(51) International Patent Classification (IPC)7: C12Q 1/06, G01N 33/536, G01N 33/543, G01N 33/53, C07H 21/04 (86) International application number: PCT/US9907/270 (87) International publication number: WO 9951/766 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: CH DE FR GB LI NL (30) Priority: 03.04.1998 US 54936 (71) Applicant: INVITROGEN CORPORATION Carlsbad, CA 92008 (US)	(72) Inventors: FERNANDEZ, Joseph, Manuel Carlsbad, CA 92008 (US) HEYMAN, John, Alastair Cardiff-by-the-Sea, CA 92007 (US) HOEFFLER, James, Paul Carlsbad, CA 92009 (US) MARKS-HULL, Heather, Lynn Oceanside, CA 92054 (US) SINDICI, Michelle, Lynn San Diego, CA 92106 (US) (74) Representative: Fiener, Josef  Postfach 12 49 87712 Mindelheim 87712 Mindelheim (DE)