(19)

(11)

EP 1 066 412 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99913467.9 (22) Date of filing: 26.03.1999

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/GB9900/966 (87) International publication number: WO 9950/449 (07.10.1999 Gazette 1999/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.03.1998 GB 9806653 (71) Applicant: ISIS INNOVATION LIMITED Summertown,Oxford OX2 7BZ (GB)	(72) Inventors: COOKSON, William, Osmond, Charles, Michael Oxford OX4 1PD (GB) BHATTACHARYYA, Sumit Cambridgeshire CB2 5BP (GB) LEAVES, Nicholas Oxford OX3 8EE (GB) (74) Representative: Shah, Punita et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)