(19)

(11)

EP 1 066 528 A1

(12)

(43) Date of publication: 10.01.2001 Bulletin 2001/02 (21) Application number: 99915200.2 (22) Date of filing: 01.04.1999

(51) International Patent Classification (IPC)7: G01N 33/68, G01N 33/50 (86) International application number: PCT/US9907/210 (87) International publication number: WO 9950/672 (07.10.1999 Gazette 1999/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.04.1998 US 80385 P (71) Applicant: BAYLOR COLLEGE OF MEDICINE Houston, TX 77030 (US)	(72) Inventors: MATZUK, Martin, M. Pearland, TX 77584 (US) ELVIN, Julia, A. Houston, TX 77025 (US) WANG, Pei Houston, TX 77025 (US) (74) Representative: Kirkham, Nicholas Andrew et al Graham Watt & Co.,Riverhead Sevenoaks,Kent TN13 2BN Sevenoaks,Kent TN13 2BN (GB)