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EP 1 067 930 A1

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(43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99912924.0 (22) Date of filing: 29.03.1999

(51) International Patent Classification (IPC)7: A61K 31/445, A61K 31/495, A61K 31/50, A61K 31/52, A61K 31/54, A61K 31/505, A61K 31/535, C07D 401/12, C07D 401/14, C07D 403/12, C07D 403/14, C07D 471/04, C07D 473/00, C07D 475/00, C07D 487/04 (86) International application number: PCT/US9906/726 (87) International publication number: WO 9951/232 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.04.1998 US 80405 P 21.07.1998 GB 9815854 (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventors: WALSH, Thomas, F. Rahway, NJ 07065 (US) UJJAINWALLA, Feroze Rahway, NJ 07065 (US) GOULET, Mark, T. Rahway, NJ 07065 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)