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(11)

EP 1 067 952 A1

(12)

(43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99916478.3 (22) Date of filing: 07.04.1999

(51) International Patent Classification (IPC)7: A61K 38/08, C07K 7/14, C12N 5/00 (86) International application number: PCT/US9907/654 (87) International publication number: WO 9952/540 (21.10.1999 Gazette 1999/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.04.1998 US 81262 P 12.06.1998 US 89024 P (71) Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA Los Angeles, CA 90007-4344 (US)	(72) Inventors: RODGERS, Kathleen, E. Long Beach, CA 90815 (US) DIZEREGA, Gere Pasadena, CA 91106 (US) (74) Representative: Grund, Martin, Dr. et al Holbeinstrasse 5 81679 München 81679 München (DE)