(19)

(11)

EP 1 067 961 A2

(12)

(88) Date of publication A3: 09.12.1999 (43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99915864.5 (22) Date of filing: 06.04.1999

(51) International Patent Classification (IPC)7: A61K 39/008, C07K 14/44, C12N 15/30 (86) International application number: PCT/GB9900/889 (87) International publication number: WO 9951/264 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.04.1998 GB 9807293 (71) Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW Glasgow G12 8QQ (GB)	(72) Inventors: MOTTRAM, Jeremy, Charles Bearsden G61 1HT (GB) COOMBS, Graham, Herbert Glasgow G12 0LZ (GB) (74) Representative: Horner, Martin Grenville  Cruikshank & Fairweather19 Royal Exchange Square Glasgow G1 3AEScotland Glasgow G1 3AEScotland (GB)