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(11)

EP 1 068 187 A1

(12)

(43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99915341.4 (22) Date of filing: 08.04.1999

(51) International Patent Classification (IPC)7: C07D 231/16, A61K 31/475, A61K 31/42, A61K 31/425, A61K 31/44, A61K 31/445, A61K 31/415, C07D 405/10, C07D 403/10, C07D 495/04, C07D 409/10, C07D 417/10, C07D 401/10, C07D 413/10, C07D 401/04, C07D 409/04, C07D 401/14, C07D 417/14, C07D 405/14 // (C07D495/04, 333:00), C07D231:00 (86) International application number: PCT/US9907/766 (87) International publication number: WO 9951/580 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 08.04.1998 US 56996 (71) Applicant: ABBOTT LABORATORIES Abbott Park,IL 60064-6050 (US)

(72) Inventors: BA MAUNG, Nwe, Y. Niles, IL 60714 (US) BASHA, Anwer Lake Forest, IL 60045 (US) DJURIC, Stevan, W. Libertyville, IL 60048 (US) GUBBINS, Earl, J. Libertyville, IL 60048 (US) LULY, Jay, R. Wellesley, MA 02181 (US) TU, Noah, P. Gurnee, IL 60031 (US) MADAR, David, J. Grayslake, IL 60030 (US) WARRIOR, Usha Green Oaks, IL 60048 (US) WIEDEMAN, Paul, E. Libertyville, IL 60048 (US) ZHOU, Xun Park City, IL 60048 (US) WAGENAAR, Frank, L. Gurnee, IL 60031 (US) SCIOTTI, Richard, J. Gurnee, IL 60031 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)