(19)

(11)

EP 1 068 225 A2

(12)

(88) Date of publication A3: 23.12.1999 (43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99919208.1 (22) Date of filing: 07.04.1999

(51) International Patent Classification (IPC)7: C07K 14/00, A61K 47/48, A61K 9/127 (86) International application number: PCT/EP9902/361 (87) International publication number: WO 9951/629 (14.10.1999 Gazette 1999/41)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 07.04.1998 EP 98106302 30.12.1998 EP 98124837 (71) Applicant: Roche Diagnostics GmbH 68298 Mannheim (DE)	(72) Inventors: KITAS, Eric, Argirios CH-4144 Arlesheim (CH) SCHLAEGER, Ernst-Jürgen D-79588 Effringen-Kirchen (DE)