(19)

(11)

EP 1 068 229 A1

(12)

(43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99915909.8 (22) Date of filing: 09.04.1999

(51) International Patent Classification (IPC)7: C07K 14/315, C12N 15/00, A61K 39/09, A61K 38/16, C07K 16/00 (86) International application number: PCT/GB9901/104 (87) International publication number: WO 9952/939 (21.10.1999 Gazette 1999/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.04.1998 GB 9807890 (71) Applicant: ACTINOVA LIMITED Cambridge CB5 8LA (GB)	(72) Inventors: BJORCK, Lars, Henrik S-223 50 Lund (SE) FRICK, Inga-Maria S-245 33 Staffanstorp (SE) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5LX London WC1R 5LX (GB)