(19)

(11)

EP 1 068 239 A2

(12)

(88) Date of publication A3: 18.11.1999 (43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99914142.7 (22) Date of filing: 25.03.1999

(51) International Patent Classification (IPC)7: C07K 14/775 (86) International application number: PCT/US9906/580 (87) International publication number: WO 9950/286 (07.10.1999 Gazette 1999/40)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 31.03.1998 US 80131 P (71) Applicant: UNIVERSITY OF CINCINNATI Cincinnati, Ohio 45267-0829 (US)	(72) Inventors: HUI, David, Y. Cincinnati, OH 45241 (US) TSO, Patrick Loveland, OH 45140 (US) (74) Representative: Baker, Karen Veronica, Dr.  Baker Associates,10 St. Peters Road Huntingdon PE29 7AA Huntingdon PE29 7AA (GB)