(19)

(11)

EP 1 068 338 A2

(12)

(88) Date of publication A3: 24.02.2000 (43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99937944.9 (22) Date of filing: 05.03.1999

(51) International Patent Classification (IPC)7: C12N 15/62, C12N 5/10, C12N 15/86, C12N 9/02, A61K 47/48, A61K 38/44, C12N 7/01 (86) International application number: PCT/GB9900/674 (87) International publication number: WO 9945/127 (10.09.1999 Gazette 1999/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.03.1998 GB 9804841 19.08.1998 GB 9818103 29.01.1999 GB 9902081 (71) Applicant: Oxford Biomedica (UK) Limited Oxford 0X4 4GA (GB)

(72) Inventors: STRATFORD, Ian, James Hope Valley,Derbyshire S32 5QD (GB) PATTERSON, Adam, Vorn Ashton-under-Lyne,Lancs OL5 0SN (GB) KINGSMAN, Susan, Mary Islip,Oxon OX5 2SF (GB) KAN, On Oxon OX14 1XS (GB) GRIFFITHS, Leigh Didcot,Oxon OX11 7RU (GB) MITROPHANOUS, Kyriacos Oxford OX4 1SZ (GB) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)