(19)

(11)

EP 1 068 354 A2

(12)

(88) Date of publication A3: 16.03.2000 (43) Date of publication: 17.01.2001 Bulletin 2001/03 (21) Application number: 99915117.8 (22) Date of filing: 30.03.1999

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US9906/893 (87) International publication number: WO 9953/095 (21.10.1999 Gazette 1999/42)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 09.04.1998 US 57871 (71) Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Cambridge, MA 02142 (US)	(72) Inventors: LANDER, Eric, S. Cambridge, MA 0213 (US) WANG, David Arlington, MA 02174 (US) HUDSON, Thomas Westmount, Quebec H3Z 2J2 (CA) (74) Representative: Holdcroft, James Gerald, Dr. et al Graham Watt & Co.,Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)