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(11)

EP 1 069 895 A2

(12)

(88) Date of publication A3: 25.11.1999 (43) Date of publication: 24.01.2001 Bulletin 2001/04 (21) Application number: 99913956.1 (22) Date of filing: 17.03.1999

(51) International Patent Classification (IPC)7: A61K 31/255, A61K 31/66, C07F 9/09, C07C 305/10, C07C 305/06 (86) International application number: PCT/US9905/943 (87) International publication number: WO 9947/101 (23.09.1999 Gazette 1999/38)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 18.03.1998 US 78375 P (71) Applicants: LXR BIOTECHNOLOGY INC. Richmond, CA 94804 (US) OXFORD ASYMMETRY LIMITED Abingdon,Oxon OX14 4SD (GB)

(72) Inventors: GODDARD, John, G. San Francisco, CA 94131 (US) PICKER, Donald, H. Summit, NJ 07901 (US) UMANSKY, Samuil, R. Richmond, CA 94805 (US) PRICE, Steven Aylesbury, Bucks HP22 5UJ (GB) WIJKMANS, Jacobus, C., H., M. Abingdon, Oxon OX14 1XA (GB) BOYD, Edward, Andrew Didcot, Oxon OX11 7QH (GB) BAXTER, Anthony, David Abingdon, Oxon OX14 5NP (GB) (74) Representative: Grosse, Wolfgang, Dipl.-Ing.  PatentanwälteHerrmann-TrentepohlGrosse - Bockhorni & Partner,Forstenrieder Allee 59 81476 München 81476 München (DE)