(19)
(11) EP 1 071 327 A1

(12)

(43) Date of publication:
31.01.2001 Bulletin 2001/05

(21) Application number: 99919952.4

(22) Date of filing: 22.04.1999
(51) International Patent Classification (IPC)7A01N 37/18, A61K 39/00, C12P 21/04, G01N 33/53
(86) International application number:
PCT/US9908/774
(87) International publication number:
WO 9953/757 (28.10.1999 Gazette 1999/43)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 22.04.1998 US 82643 P

(71) Applicants:
  • Merck & Co., Inc. (a New Jersey corp.)
    Rahway, N.J. 07065 (US)
  • John Hopkins University
    Baltimore, MD 21205 (US)
  • MERCK FROSST CANADA INC.
    KirklandQuebec H9H 3L1 (CA)

(72) Inventors:
  • THORNBERRY, Nancy
    Rahway, NJ 07065 (US)
  • ROSEN, Antony
    Baltimore, MD 21205 (US)
  • CASCIOLA-ROSEN, Livia
    Baltimore, MD 21205 (US)
  • ANDRADE, Felipe, A.
    Baltimore, MD 21205 (US)
  • NICHOLSON, Donald
    Kirkland, Quebec H9H 3L1 (CA)
  • ROY, Sophie
    Kirkland, Quebec H9H 3L1 (CA)

(74) Representative: Hiscock, Ian James et al
European Patent Department,Merck & Co., Inc.,Terlings Park,Eastwick Road
Harlow,Essex CM20 2QR
Harlow,Essex CM20 2QR (GB)

   


(54) AUTOANTIGENIC FRAGMENTS, METHODS AND ASSAYS