(19)

(11)

EP 1 071 436 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99903347.5 (22) Date of filing: 25.01.1999

(51) International Patent Classification (IPC)7: A61K 35/00 (86) International application number: PCT/US9901/464 (87) International publication number: WO 9937/313 (29.07.1999 Gazette 1999/30)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.01.1998 US 88357 P 31.03.1998 US 80041 P (71) Applicant: Genzyme Corporation Framingham, MA 01701-9322 (US)	(72) Inventors: ROBERTS, Bruce, L. Milford, MA 01757 (US) NICOLETTE, Charles, A. Marlborough, MA 01752 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing. et al Patent- und Rechtsanwälte,Possartstrasse 20 81679 München 81679 München (DE)