(19)

(11)

EP 1 071 454 A1

(12)

(43) Date of publication: 31.01.2001 Bulletin 2001/05 (21) Application number: 99919976.3 (22) Date of filing: 23.04.1999

(51) International Patent Classification (IPC)7: A61K 39/29, A61K 39/295, C12Q 1/70, C12N 7/01, C07H 21/02 (86) International application number: PCT/US9908/850 (87) International publication number: WO 9955/366 (04.11.1999 Gazette 1999/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.04.1998 US 82964 P (71) Applicant: WASHINGTON UNIVERSITY St. Louis, MO 63130 (US)	(72) Inventors: RICE, Charles, M. University City, MO 63130 (US) FROLOV, Ilya St. Louis, MO 63129 (US) McBRIDE, M., Scott Madison, WI 53711 (US) LEE, Young-min St. Louis, MO 63123 (US) AGAPOV, Eugene, V. St. Louis, MO 63105 (US) MYERS, Tina, M. St. Louis, MO 63123 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn EllisYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)